Manufacturer: INTAS
Pharmaceutical name: Mosapride Citrate
Pack: 10 pills (5 mg)
Moza is indicated for the treatment of severe reflux oesophagitis, also called gastroesophageal reflux disease (GORD), particularly when other treatments have failed or are not suitable. Additionally, Moza is used to address gastroparesis, or delayed gastric emptying, which leads to prolonged food retention in the stomach due to weakened muscle contractions and can result in various unpleasant symptoms, such as vomiting, nausea, heartburn, and dyspepsia. Moza aids in restoring the natural rhythm of muscle contraction and relaxation in the stomach, alleviating gastrointestinal issues like heartburn and dyspepsia (indigestion and abdominal discomfort) that arise from the acidic contents of the stomach refluxing into the oesophagus.
Moza contains Mosapride, a gastric prokinetic agent and serotonin (5HT) receptor agonist. The Mosapride in Moza specifically targets the 5HT4 receptor located in the stomach and does not interact with dopamine or acetylcholine receptors1. Activation of the 5HT4 receptor enhances the release of acetylcholine by the nerves that supply the stomach, directly stimulating the stomach muscles to promote peristalsis, the natural waves of contraction that push food towards the intestine. This prokinetic effect of mosapride in Moza enhances gastrointestinal motility, accelerates gastric emptying, and alleviates pressure on the esophageal sphincter (the muscle at the junction of the oesophagus and stomach), thereby helping to prevent reflux into the oesophagus.
The most frequently reported side effects of Moza include: diarrhoea, dry mouth, headaches, nausea, insomnia, abdominal pain, and dizziness.
Moza should not be used if you: have an allergy to mosapride or any of its components; are pregnant or breastfeeding; have kidney or liver disorders or respiratory failure; are taking medications that might prolong the QT-interval, including the antimalarial quinine, the antihistamine terfenadine, certain antiarrhythmic drugs like amiodarone, quinidine, flecainide, sotalol, tricyclic antidepressants such as amitriptyline, and some antipsychotics like phenothiazines, haloperidol, or risperidone, as these may increase the risk of QT prolongation; or are on medications that could interact with Moza, such as macrolide antibiotics like erythromycin, which raises the concentration of mosapride.
You should take Moza with a glass of water three times a day, either with or without food. Your dosage will be based on the condition being treated and your doctor's guidance. Continue taking Moza for the duration recommended by your doctor, but not exceeding two weeks. Continuous use of Moza is not advised if no improvement in GI symptoms is seen after two weeks of treatment.
If you forget a dose of Moza, take it as soon as you recall, unless it’s nearly time for your next dose; in that case, skip the missed dose. Do not take two doses at once.
Store your Moza below 25°C in a cool, dry location.